I do get some questions asking for an FS-UAE version running natively on Apple silicon / M1. The short answer is that it is possible to build a working version for M1, but I don’t yet provide official builds due to not having access to the hardware. Please see this recent thread on the English Amiga Board for more information: https://eab.abime.net/showthread.php?t=106970.
There has also been reports about joystick/gamepad devices not working on M1 hardware with FS-UAE 3.0.5. I have created newer builds – available here for now: https://eab.abime.net/showthread.php?t=105950 – which are reported to fix the issue 🙂
EDIT: Official ARM64 builds for Apple silicon / M1 are coming.